SciAntics

Sciantics? Really? Sorry folks, couldn't think of a better name! Anyways, this blog is dedicated to science news, articles, and just plain information that needs to be shared for the sake of science, education, and learning! I don't want to divulge into too much about my personal life on this blog, so i'll just say that I'm a biology/ chemistry major. You'll most likely see posts along these lines along with the ocasional physics and astronomy posts.

Disclaimer: This blog, and I have no connection to most of these outside articles, and pictures. All articles, and pictures are sourced accordingly, and if you see a post something sourced to you and wish for it to be removed, please notify me, and it will be removed promptly.

Researchers find molecule that prevents Type 1 diabetes in mice Researchers at the University of Colorado School of Medicine have found a specific molecule that can prevent the development of type 1 diabetes in mice and has a similar effect on human cells from diabetic patients. The findings, published in the latest edition of The Journal of Immunology, signal a new and promising direction in the fight against type I diabetes along with other autoimmune disorders like rheumatoid arthritis, multiple sclerosis and celiac disease. The researchers were looking for small molecules capable of occupying pockets along a protein binding groove. Some of the molecules got into these pockets and inhibited the presentation of insulin to immune cells while others enhanced it. Type 1 diabetes is characterized by the body’s inability to manufacture insulin because its own immune system is attacking it. The incidence of the disease has doubled in each of the last two decades. Michels and Eisenbarth found that the compound Glyphosine enhanced insulin presentation and prevented diabetes in mice genetically modified to develop type 1diabetes. It had the same effect on human cells. The mice remained disease-free as long as they received daily injections of the compound. It was not as effective on mice that already had diabetes. Michels said that based on the two and a half year study, it would be feasible to genetically screen individuals likely to develop type 1 diabetes and begin a therapy regimen using these compounds to prevent the onset of the disease. Right now, doctors can predict who will get type 1diabetes about 90 percent of the time. “This technique would also apply to other autoimmune disorders like arthritis and celiac disease,” Michels said. “The principals are the same.” The next step is to focus specifically on human cells to try and develop new therapies for clinical use. That could be at least five years away. Read more (Via Biology News Net) (Source: University of Colorado Denver) Image hosted by Flicker (Via photoeditorvision)

Researchers find molecule that prevents Type 1 diabetes in mice

Researchers at the University of Colorado School of Medicine have found a specific molecule that can prevent the development of type 1 diabetes in mice and has a similar effect on human cells from diabetic patients.

The findings, published in the latest edition of The Journal of Immunology, signal a new and promising direction in the fight against type I diabetes along with other autoimmune disorders like rheumatoid arthritis, multiple sclerosis and celiac disease.

The researchers were looking for small molecules capable of occupying pockets along a protein binding groove. Some of the molecules got into these pockets and inhibited the presentation of insulin to immune cells while others enhanced it.

Type 1 diabetes is characterized by the body’s inability to manufacture insulin because its own immune system is attacking it. The incidence of the disease has doubled in each of the last two decades.

Michels and Eisenbarth found that the compound Glyphosine enhanced insulin presentation and prevented diabetes in mice genetically modified to develop type 1diabetes. It had the same effect on human cells. The mice remained disease-free as long as they received daily injections of the compound. It was not as effective on mice that already had diabetes.

Michels said that based on the two and a half year study, it would be feasible to genetically screen individuals likely to develop type 1 diabetes and begin a therapy regimen using these compounds to prevent the onset of the disease. Right now, doctors can predict who will get type 1diabetes about 90 percent of the time.

“This technique would also apply to other autoimmune disorders like arthritis and celiac disease,” Michels said. “The principals are the same.”

The next step is to focus specifically on human cells to try and develop new therapies for clinical use. That could be at least five years away.

Read more (Via Biology News Net)

(Source: University of Colorado Denver)

Image hosted by Flicker (Via photoeditorvision)

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  1. gutsandbrains reblogged this from polymath4ever
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    Genetic screening for Type I becoming feasible? Nice. And just a few months ago, when I was taking molecular cell bio,...
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